Skin metastases as initial manifestation of esophageal squamous-cell carcinoma

Skin metastases as initial manifestation of esophageal squamous-cell carcinoma.

Esophageal cancer is the sixth most common cause of cancer-related deaths worldwide. Patients with esophageal cancer usually present with locally advanced disease with presence of metastases at diagnosis (1). Squamous-cell carcinoma is the most common histologic subtype in the proximal and middle thirds of the esophagus. Skin metastases from visceral tumors are rare, with a prevalence of up to ...

Role of Brg1 in progression of esophageal squamous cell carcinoma

Objective(s): Epigenetic regulation of gene expression can be carried out through chromatin remodeling enzymes such as SWI/SNF. Brg1 also known as SMARCA4 is a catalytic subunit of SWI/SNF, which is necessary for MMPs expression. Matrix metalloproteinases (MMPs) are known as important player enzymes during tumor progression and metastasis. Aberrant epigenetic modification of chromatin should be...

scalp lesion as an initial presentation of esophageal squamous cell carcinoma

esophageal cancer is the ninth most common malignancy.the incidence of esophageal cancer varies greatly among regions of the world and occurs at a high frequency in asia and northern iran. we report the case of an 80-year-old man with esophageal squamous cell carcinoma who initially presented with a metastatic scalp lesion. esophagoscopy was performed and a lesion was located in the mid-portion...

TELOMERASEACTIVITYIN IRANIAN PATIENTS WITH ESOPHAGEAL SQUAMOUS CELL CARCINOMA

Telomerase activation is one of the main pathways to immortalize cancer cells. In many kinds of cancer cells, this special reverse transcriptase stabilizes and elongates telomeres and prevents telomere erosion that naturally occurs in every cell division. Esophageal cancer is the fifth most frequent cause of cancer death worldwide, and is highly associated with alcohol, smoking, cultural ha...

[Skin metastases as the initial presentation of pancreatic carcinoma].